The Pahlberg Lab is using a comprehensive approach spanning from molecules to behavior utilizing very specific animal models. We have several methods that are of particular importance to provide leverage in answering our research questions:
We use state-of-the art electrophysiological and behavioral experiments combined with molecular and genetic methods of the highest standard. These experiments will be performed on several unique genetically modified mouse lines that display altered photoresponses and signaling properties, as well as other mammalian and amphibian species whose variations in retinal anatomy and physiology can further inform our research questions. Our approach allows us to study the optimal processing of sensory signals in the same system at the molecular, cellular, systems, and behavioral level, and unravel mechanisms underlying signal processing in neural networks.